Date: 14/07/2009
Source : University of Liège
A recent Clinical Study was conducted at the University of Liège on Growth Hormone deficient adult patients (AGHD). The objective of this clinical study was to evaluate thymic function in AGHD, as well as the repercussion upon thymopoiesis of GH treatment for restoration of GH/IGF-1 physiological levels.
It revealed that for patients with AGHD under GH treatment, GH withdrawal decreases thymic T cell output, as well as intrathymic T cell proliferation. These parameters of thymus function are completely or partially restored one month after GH resumption. These data indicate that the functional integrity of the somatotrope GH/IGF-1 axis is important for the maintenance of a normal thymus function in human adults.
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005668
Attached document : Article_37.pdf (219.8kb)
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